O uso crónico de nimesulida prejudica a hipertrofia cardíaca induzida pelo exercício
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Resumo
A nimesulida é um anti-inflamatório não esteroidal (AINE) utilizado para o tratamento de dor e inflamação. Este estudo exploratório avaliou se a administração de nimesulida concomitantemente ao treinamento resistido (TR) estava associada a diferenças no desempenho, na razão massa cardíaca/massa corporal e na função cardíaca ex vivo. Ratos Wistar machos foram distribuídos em três grupos: CTRLL (controle, n = 4), TR (treinamento resistido por 8 semanas, n = 7) e COMB (mesmo protocolo de TR associado à nimesulida, 2,5 mg/kg, n = 7). Após a intervenção, os corações foram estudados em preparação de Langendorff durante estabilização basal, 30 min de isquemia global e 60 min de reperfusão. O TR e o COMB aumentaram significativamente a capacidade de carga em relação ao período pré-intervenção (p < 0,0001), sem diferença entre os dois grupos treinados ao final do protocolo. A razão massa cardíaca/massa corporal foi maior no TR em comparação ao CTRLL e apresentou resposta distinta no COMB. O tamanho do infarto não diferiu significativamente entre os grupos, e não houve evidência conclusiva de melhora da recuperação da pressão desenvolvida do ventrículo esquerdo após isquemia-reperfusão. Assim, a associação com nimesulida não alterou o ganho de força, enquanto a resposta morfométrica diferiu daquela observada com treinamento isolado. Devido ao pequeno tamanho amostral e à ausência de um grupo sedentário tratado com nimesulida, estes achados devem ser considerados exploratórios e não permitem atribuir causalmente ao fármaco as diferenças observadas.
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